SLAS2016 saw the introduction of ameon, the new lifetime reader for robust high-throughput biochemical screening
We were proud to present the new lifetime screening solutions brought to you by TTP Labtech’s ameon reader and Almac’s FLEXYTE lifetime reagents. This collaboration enables straightforward implementation of the fluorescence lifetime technology into even the most challenging HTS and profiling workflows.
miniaturised, low-cost single-cell transcriptome sequencing
In this tutorial, Dr. Louise Laurent, MD, PhD (UC San Diego) presents the use of mosquito positive displacement liquid handlers in preparing 2 µL Nextera XT libraries with as little as 20 pg of cDNA. Dr. Laurent also demonstrates how this automated high-throughput method saves time and money.
making 1536 direct dilution of compounds possible with mosquito HTS, a low-volume automated liquid handler
Jose Quiroz, Associate Director, Compound Management (Dart NeuroScience LLC) talks about how TTP Labtech’s automated low volume liquid handler, mosquito HTS can create a semi-direct dilution series into 1536-well plates. This method has many benefits over the gold standard serial dilution method.
high-throughput mass spectometry using mosquito HTS
The new, fully automated MALDI PharmaPulse™ system is a high-throughput MS solution that has been developed to screen over 100,000 samples per day.
introducing the new sol-RTM beads for mirrorball
mirrorball and the new sol-RTM beads enable a multiplexed assay approach for screening and hit characterisation assays using both cell- and bead-based methods. We presented how the versatile nature, and advantages of multiplexing assays using mirrorball can improve the productivity of biologics discovery.
eliminating the false negatives in ATP-luminescence cell health assays by the use of a phenotypic assay approach
ATP-luminescence measurements can significantly overestimate toxicity and underestimate potency, leading to false-negative viability/efficacy hits. Here we show the development and implementation of an alternative no-wash HCA assay, which eliminates common problems associated with ATP-luminescence measurements. We compare the drug-responses of several well-characterised anti-cancer drugs on HeLa cells, measured by both the HCA assay and a commercial ATP-luminescence detection system, and highlight key differences between the measurements.