blog: Unleashing the power of a single cell

TTP Labtech’s mosquito liquid handlers for automated, high-throughput, low-cost sequencing

Dr. Louise Laurent (University of California, San Diego, USA) and her team have recently published a miniaturised method for single-cell RNA library preparation that has reduced costs by 90% whilst increasing throughput and ensuring the high quality of libraries. (Sergio, MC et al. JALA 2016)!

In 1670, Antony van Leewenhoek made it possible to visualise a single cell under a microscope, now we have the potential to examine the entire genetic make-up of large populations of single cells simultaneously.

Advances in next-generation sequencing (NGS) methods have enabled whole transcriptome sequencing of single cells in high-throughput. A primary limitation of sequencing is cost. It is true that the cost of sequencing has now decreased, but this has not been the case for the library preparation step. If this part of the process could be miniaturised then the cost of library preparation could also be reduced. To achieve this, we have developed the ideal platform – reproducible, low-cost, low-volume benchtop liquid handlers designed for precious samples of varying viscosity!

the ‘how to’!

The published miniaturised method separates single cells into individual microchambers where the reverse transcription reaction generates high-quality cDNA. Using TTP Labtech’s mosquito HTS liquid handler, as little as 20 pg of cDNA is used with the Nextera XT library preparation kit (Illumina).

applying the new method!

To assess the quality of the libraries, Dr. Louise Laurent’s group applied this system to analyse pancreatic differentiation of human embryonic stem cells.

After differentiation, the cell cultures were dissociated to single-cell suspensions. cDNA libraries were generated from 20 pg of cDNA for three final reaction volumes (2-, 4- and 8- µL) in quadruplicate, in 384-well plates.

5-fold reduction of cDNA and 90% reduction in costs

The resulting single-cell RNA-seq data demonstrated that even at low reaction volumes it was possible to distinguish between cells at different stages of differentiation and also between individual cells within each stage (Fig 1). There was high reproducibility with a greater than 5-fold reduction of input cDNA in a 2 uL reaction volume. In addition, miniaturisation provided total cost savings of 90%.


Fig 1. 2D principal component analysis demonstrates a clear separation between the libraries from each of the four cells. Importantly, the libraries did not cluster according to reaction volume, even within a single cell.

confirmed accurate and reproducible pipetting

mosquito HTS provided accurate and reproducible pipetting for each of the steps in the sequencing process. In addition, TTP Labtech’s mosquito HV and 384 magnet (SZZ00136) enabled efficient bead clean-up of the libraries before they were sequenced on an Illumina HiSeq 2500.

“The workflow we have developed, in partnership with TTP Labtech, has the potential to provide researchers with significant cost savings while maintaining the quality of single cell sequencing. The instrument cost and their ease-of-use make the mosquito liquid handlers viable options for labs that would like to scale-down and automate next-generation sequencing sample preparation.” commented Dr Laurent, Associate Professor, UCSD.

So if you want to save on sample and reduce costs but still want to analyse hundreds to thousands of single cells per project, then try using this method with TTP Labtech’s mosquito liquid handlers.

Listen to Dr. Laurent discuss this work in our webinar or download the app note for more details.

If you are attending ASHG2016, Vancouver, Canada (18-22th October 2016) then come along to discuss your NGS needs at booth #1326 anytime during the conference!

Full recap of this years DOT2016

Thanks to everyone who spoke with us at #BostonDOT16

In case you missed it, you can find a full recap!

Our Head of Applications, Dr. Paul Wylie presented a lecture, ameon: Flexyte Protein Interaction Assays, on the 21st September and he also presented our poster (#160) all week: Multiplexed cell- and bead-based assays in a no-wash format for biologics screening and characterization

We showcased our answers to challenges in which are common in drug target screening applications.

mirrorball no-wash cytometry – download the brochure here

  • homogeneous hands-off protocols
  • productive multiplexed assays
  • simple template-driven software
  • reliable plate-based no clogging design

mosquito low-volume liquid handlers – download the brochure here

  • true positive displacement pipetting
  • low dead volume
  • flexible plate types
  • fast throughput within 25-1500 nL volume range

sample storage – download the brochure here

  • arktic the -80°C store
  • comPOUND the -20°C store
  • flexible modular system
  • secure double refrigeration system
  • small footprint, high density storage
  • sample tracking & LIMS integration

blog: The importance of being a consumable!

TTP Labtech’s sol-R microplate ensures confidence in your data!

Consumables are goods that are capable of being consumed by being destroyed, dissipated, wasted or spent. This definition implies a lack of worth but in the case of biological assays, the consumable commandeers a much higher status. If consumables are not designed appropriately, even when they are used alongside the most expensive piece of equipment in your lab, they will not produce high quality data.

Successful high-throughput screening relies on high-quality data. This needs to be considered throughout the whole process of sample collection, storage and processing. One advance that has become an accepted necessity in large screening laboratories is automation which reduces errors associated with manual operation and enables smaller volumes of materials to be processed. The full potential of automated systems can only be achieved with the help of optimised consumables.  Particularly at small volumes, pipetting accuracy and plate compatibility can increase productivity and reduce costs. This can also lead to a reduction in the number of replicates required, enabling more samples to be screened in the same time period.

TTP Labtech has recently expanded their range of screening consumables to include the sol-R™ microplate which is an affordable, high-quality, optically clear 384-well imaging plate. The plates are available in sterile and TC treated, or non-sterile, non-TC treated formats. Their optimised design provides reliable focus, good well positioning and QC tests report <3% CVs across a microplate. Although these plates have been designed to be compatible with TTP Labtech’s acumen and mirrorball fluorescence cytometers, they are equally compatible with other microscope-based imaging devices providing the customer with added flexibility.

Together with TTP Labtech’s sol-R bead range, the functionality of mirrorball can now be extended into multiplexed bead-based immunoassay applications so that there is no need to look any further for your complete solution to your multiplexed screening assays.

If you would like to find out more about TTP Labtech and their phenotypic screening solutions, including their new range of sol-R consumables, please go to the website or contact

press release: TTP Labtech and University of California, San Diego, collaboration accelerates single cell genomics research

Cambridge, UK, and San Diego, CA, USA, 14th September 2016

TTP Labtech Ltd, a global leader in the design and development of automated instrumentation and consumables for life science applications, and the University of California San Diego (UC San Diego), have announced that their collaboration has resulted in a new workflow for single cell sequencing, which reduces the cost of sample preparation by 90%. The workflow, which has been published in the Journal of Laboratory Automation, was developed through the combination of UC San Diego’s expertise in genomics and the use of TTP Labtech’s mosquito liquid handlers, which can pipette nanolitre to microlitre volumes with high accuracy and reproducibility, to miniaturise and automate the process.

Although single-cell genomics is advancing rapidly, researchers face challenges linked with reproducibility, sensitivity, scalability and cost, particularly when trying to miniaturise high-throughput applications. To maximise accuracy and precision, library prep protocols recommend volumes that are within the range of manual pipettes or large-volume liquid handlers. However, only a small proportion of each of the libraries prepared will be required for sequencing. The focus of UC San Diego’s partnership with TTP Labtech was to miniaturise single-cell RNA library prep reaction set-up, to minimise sample and reagent requirements. The resulting workflow has been shown to reduce library prep costs by up to 90% while maintaining throughput, accuracy and reproducibility.

The miniaturisation of library prep volumes was achieved using TTP Labtech’s mosquito HTS and HV liquid handlers, which accurately dispense volumes between 25 nL and 1.2 μL and 0.5 to 5 μL, respectively. Both instruments use true positive-displacement pipetting technology, which maintains volumetric accuracy even for highly viscous liquids, enabling high concentration gDNA to be handled, to save on reagent cost and sample input. To assess the quality of the libraries, UC San Diego applied the workflow to analyse pancreatic differentiation of human embryonic stem cells. The resulting single-cell RNA-sequencing data were analysed to determine the reproducibility of this system and its ability to distinguish not only between cells at different stages of differentiation but also between individual cells within each stage.

Joby Jenkins, Product Manager, TTP Labtech, commented: “Single cell sequencing requires large numbers of samples to be handled in order to provide valid data based on population studies. Reproducibility and sensitivity, as well as scalability and cost, can be limiting factors when large numbers of cells are analysed, and we are very pleased that our partnership with UCSD has achieved our goal of improving sample prep for single cell genomics research.”

Dr Louise Laurent, MD, PhD, Associate Professor, UC San Diego, said: “The workflow we have developed, in partnership with TTP Labtech, has the potential to provide researchers with significant cost savings while maintaining the quality of single cell sequencing. The instrument cost and their ease-of-use make the mosquito liquid handlers viable options for labs that would like to scale-down and automate next-generation sequencing sample preparation.”

TTP Labtech will be presenting a poster on the published workflow at the Single Cell Genomics Conference, 14-16 September 2016, Wellcome Genome Campus, Hinxton, UK and exhibiting at ASHG 2016 booth #1326, 18-22 October 2016, Vancouver, BC, Canada

news: TTP Labtech introduces sol-R microplates

TTP Labtech introduces sol-R microplates to enhance the productivity and performance of laser scanning cytometers

New microplates are an extension of TTP Labtech’s consumables portfolio

Cambridge, UK, 13th September 2016: TTP Labtech Ltd, a global leader in the design and development of automated instrumentation and consumables for life science applications, today announced the commercial launch of its sol-R™ microplates. The new sol-R consumables range is designed to amplify the productivity gains delivered by laser-scanning fluorescence cytometers by enabling users to deliver reliable decision making data faster.

Validated for use with TTP Labtech’s acumen and mirrorball cytometers, sol-R microplates provide the convenience of an off-the-shelf consumable and the benefits of custom design. Due to plate flatness stringencies and the optical clarity of the film, these new microplates have been developed for use with microscope-based imaging devices, enabling users to transfer seamlessly between devices. Also included in the portfolio are the industry-proven sol-R coded beads for secreted protein quantification in multiplexed no-wash immunoassay screens that truly revolutionise the immunoassay workflow.

Sarah Payne, mirrorball Product Manager, TTP Labtech, said: “Enhancing laboratory efficiency is the key driver for all our product development. sol-R microplates deliver optimal data quality for multiplexed, no-wash, immunoassay and phenotypic applications while shortening the time lag between installation and productive screening. With guaranteed performance reliability, sol-R microplates enable enhanced workflow productivity and confidence in screening results.”

The sol-R microplates are available in sterile and tissue culture treated, or non-sterile, non-tissue culture treated formats.

The new sol-R microplates are sold exclusively through TTP Labtech. For more information please click here


blog: news from the world of protein crystallography

read the latest labCrystal success stories from your peer crystallographers

Ever wondered how you can fit just a few more hours into the day and gain that vital extra cup of coffee?

Now imagine if you could set up 96 drops in less than 2 minutes with the added bonus that 20x more time protein crstallograhpy experiments can be achieved using mosquito Crystal for automated drop setting (50 nL of protein per drop) compared to a manual set-up

Don’t just take our word for it; the new edition of labCrystal magazine describes how our mosquito and dragonfly liquid handlers have helped researchers to gain more from their crystallisation experiments and, significantly shorten the time taken to get the structure they need.

The studies presented in labCrystal describe how successful TTP Labtech’s mosquito and dragonfly have been in making it possible to screen and optmise more conditions in a shorter space of time:

  • Dr Chris Ulens, Katholieke Universiteit, Belgium, in collaboration with Janssen Pharma describes an innovative fragment screening method that identifies potential allosteric drug binding sites of a receptor involved in ion channel diseases. Thanks to the mosquito’s low pipetting volumes, an average of 1,000 conditions could be screened per complex leading to high-throughput identification of crystallisation conditions within 1-2 weeks
  • Dr. Steven Johnson and Dr. Matt Cottee, Oxford University, UK have used X-ray crystallography to analyse a protein involved in centriole assembly (Ana2). mosquito Crystal and dragonfly enabled multiple screening conditions to be tested and optimised which resulted in the determination of a high resolution structure
  • Dr Larissa Podust, University of California, San Diego, USA and Dr Hugues Ouellet, University of Texas, USA describe the structural determination of a transcription repressor, KstR co-crystallised with a cholesterol inducer or the KstR DNA operator. KstR regulates cholesterol catabolism and virulence in Mycobacterium tuberculosis. Both mosquito and dragonfly were essential for low-volume crystallisation and optimisation when concentrations of each component in the mix varied in small increments

Dr David Hargreaves, AstraZeneca, UK describes a novel low-volume, high-throughput soaking method developed for screening a fragment-based lead generation library. The success of this soaking method relied on the accuracy and reproducibility of mosquito Crystal’s low-volume pipetting.

And finally, labCrystal describes how mosquito LCP has been integral to GPCR membrane protein crystallisation. Many of these studies have produced multiple Nature papers and this article highlights Heptares Therapeutics’ work in this field.

If you are interested in learning more about any of these studies, then why not download a copy of labCrystal from our website today.

Do you have an interesting story that you would like to present to the Crystallography community, then we’d love to hear form you and hopefully see your work in a future edition!

>> get in touch at

blog: DNA storage – to freeze or not to freeze?

DNA storage

  • About 5-6 million DNA samples (nearly 10% of the UK’s population) are currently being stored on the UK Police National DNA database (NDNAD). It is the largest DNA database in the world, as a proportion of the population.
  • The American national DNA Index (NDIS) contains about 15 million DNA samples (approximately 5% of the US population).

In addition to these national databases, there are numerous biobanks and smaller research and clinical groups that store DNA. With such large numbers of samples being stored around the world, it is surprising to find many different storage practices.

Although freezing DNA at either -20oC or -80oC is widely accepted, there has been a drive, mainly in the area of forensics, to validate storage of DNA at room temperature (20 – 25oC). This would enable DNA to be stabilised on site before transporting to a forensic laboratory. Storing DNA at room temperature would also reduce the costs associated with long-term freezer storage. Most of the published studies in this field utilise a novel medium or minicapsule to protect the DNA from degradation at room temperature [1-5].

It is also possible to store DNA at 4oC. This is common practice for short-term storage but how stable is DNA over a longer period of time? There is very little scientific literature on this subject, but one study has demonstrated that DNA stored in a Tris-based buffer with an added chelator, rather than in water, is stable at 4oC for at least 16 years [6]. Storing samples at 4oC in an automated storage system avoids repetitive freeze thaw cycles, maintains sample integrity, reduces the cost and is more reliable than a subzero storage system.

Before deciding on what temperature to store your DNA at, it is important to understand how the DNA is going to be used.

  1. how many times will the sample be used? freeze thawing the sample may have a greater detrimental effect on the DNA than storing as a liquid at 4oC or RT
  2. what is it going to be used for? some DNA assays may be more robust than others
  3. how long will it be stored for? requirements for long term storage may differ from that of short term
  4. will it need to be transported? DNA may be collected offsite and/or be shipped to various locations

The relationship between biological activity and temperature

Temperature has a strong influence on protein dynamics: lower the temperature, lower the activity and greater the stability of the sample. Freezing changes the molecular entity of a sample; in the case of water changing from liquid to solid during the freezing process there will be a reduction in molecular mobility and in the case of enzyme activity, a reduction in reaction/activity rates will be experienced (see previous blog on the physics of freezing).

DNA degrades over time and just how long it lasts depends on how well it is preserved. To understand how freezing affects DNA degradation it is important to understand what actually causes DNA to degrade:

  1. Nucleic acids are sensitive to depurination, depyrimidination, deamination and hydrolytic cleavage. All these processes are acid-catalysed processes and are affected by ionic strength of the solution. Eluting DNA in a Tris-based buffer, rather than water can inhibit these processes, however some downstream PCR reactions can be inhibited by Tris and therefore the DNA can only be eluted in water.
  2. Nuclease contamination – this is more likely to occur with DNA eluted in water which contains nucleases. Nucleases can also be introduced into the DNA whilst working with the samples. As above, eluting DNA in a Tris-based buffer, rather than water can inhibit these processes.
  3. Oxidation – contamination by transition metals can increase oxidation levels which produce free radicals and react with compounds causing DNA degradation. Degradation can be avoided by de-metalating all components involved in DNA storage using chelating agents.

Whatever temperature you decide to store your DNA samples at, TTP Labtech have an automated solution to meet your needs. Based on pneumatic technology, comPOUND (at room temperature, 4oC or -20oC) and arktic (-80oC) automated tube-based stores are designed to fit into any lab and can be linked to grow with your expanding collection. If you would like to find out more about TTP Labtech and their DNA storage solutions, please go to the website or contact


  1. Cayuela, JM et al. A novel method for room temperature distribution and conservation of RNA and DNA reference materials for guaranteeing performance of molecular diagnostics in onco-hematology: A GBMHM study. Clin Biochem. 2015 Oct;48(15):982-7A
  2. Howlett, SE et al. Evaluation of DNAstable for DNA storage at ambient temperature. Forensic Sci Int Genet. 2014 Jan;8(1):170-8
  3. Lee SB, et al. Assessing a novel room temperature DNA storage medium for forensic biological samples. Forensic Sci Int Genet. 2012 Jan;6(1):31-40
  4. Frippiat, C et al. Evaluation of novel forensic DNA storage methodologies.Forensic Sci Int Genet. 2011 Nov;5(5):386-92
  5. Morgan, J et al. Advanced technology for storage and transport of purified DNA from umbilical cord blood prior to use in human leukocyte antigens typing and whole-genome microarray analysis. Biopreserv Biobank. 2010 Sep;8(3):133-8
  6. Hartmann, C et al. Stable 16-year storage of DNA purified with the QIAmp DNA blood mini kit. Application note QIAGEN Gmbh, Germany

We summarised SLAS2016 for you!

SLAS2016 saw the introduction of ameon, the new lifetime reader for robust high-throughput biochemical screening

We were proud to present the new lifetime screening solutions bameon_featured_imagerought to you by TTP Labtech’s ameon reader and Almac’s FLEXYTE lifetime reagents. This collaboration enables straightforward implementation of the fluorescence lifetime technology into even the most challenging HTS and profiling workflows. 

>> Watch the recorded tutorial!

>>View the poster!

miniaturised, low-cost single-cell transcriptome sequencing

InSLAS2016 tutorial Louise this tutorial, Dr. Louise Laurent, MD, PhD (UC San Diego) presents the use of mosquito positive displacement liquid handlers in preparing 2 µL Nextera XT libraries with as little as 20 pg of cDNA. Dr. Laurent also demonstrates how this automated high-throughput method saves time and money.

>> Watch the recorded tutorial!

>> Read the open source JALA publication!

>> View the poster

making 1536 direct dilution of compounds possible with mosquito HTS, a low-volume automated liquid handler

Jose Quiroz, Associate Director, Compound Management (Dart NeuroScience LLC)  talks about how TTP Labtech’s automated low volume liquid handler, mosquito HTS can create a semi-direct dilution series into 1536-well plates. This method has many benefits over the gold standard serial dilution method.

>> Read the SLAS2016 poster!


high-throughput mass spectometry using mosquito HTS

The new, fully automated MALDI PharmaPulse™ system is a high-throughput MS solution that has been developed to screen over 100,000 samples per day.

>> View the brochure! 

introducing the new sol-RTM beads for mirrorball

mirrorball and the new sol-RTM beads enable a multiplexed assay approach for screening and hit characterisation assays using both cell- and bead-based methods. We presented how the versatile nature, and advantages of multiplexing assays using mirrorball can improve the productivity of biologics discovery.

>> View the poster

eliminating the false negatives in ATP-luminescence cell health assays by the use of a phenotypic assay approach

ATP-luminescence measurements can significantly overestimate toxicity and underestimate potency, leading to false-negative viability/efficacy hits. Here we show the development and implementation of an alternative no-wash HCA assay, which eliminates common problems associated with ATP-luminescence measurements. We compare the drug-responses of several well-characterised anti-cancer drugs on HeLa cells, measured by both the HCA assay and a commercial ATP-luminescence detection system, and highlight key differences between the measurements.

>> View the poster


blog: unleashing the power of a single cell through automated, high-throughput, low-cost sequencing

In 1670, Antony van Leewenhoek made it possible to visualise a single cell under a microscope, now we have the potential to examine the entire genetic make-up of hundreds of single cells simultaneously.

Advances in next-generation sequencing (NGS) methods have enabled whole transcriptome sequencing of single cells in high-throughput. The main limitation of sequencing is cost. It is true that the cost of sequencing has now decreased, but this has not been the case for the library preparation step. If this part of the process could be miniaturised then the cost of library preparation could also be reduced. This sounds simple until you have tried to pipette very small volumes of reagents and samples using manual or large volume automated systems.

We have found the answer – reproducible, low-cost, low-volume sequencing on the benchtop!

At SLAS2016 international conference, San Diego (January 23-27th 2016) Dr. Louise Laurent (University of California, San Diego) will discuss how TTP Labtech’s mosquito® nanolitre liquid handler has enabled new strategies to be developed for low-cost single-cell transcriptome sequencing.

In this talk, Louise will present results indicating that combining the C1 Single-Cell RNA Seq Auto Prep System (Fluidigm Corp., US) for cDNA production, along with mosquito HTS (TTP Labtech) reproducibly yields high-quality single-cell RNAseq libraries at reaction volumes down to 2 ul, which can be used to identify biological differences between single cells.

The C1 Single-Cell RNA Seq Auto Prep System provides automated separation of single cells into individual microchambers where the reverse transcription reaction using SMARTer template-switching technology (Clontech Laboratories, Inc., US) generates high-quality cDNA. Using mosquito HTS, as little as 20 pg of cDNA was used as input into the Nextera XT library preparation kit (Illumina).

mosquito HTS employs true positive-displacement liquid transfer to handle nanolitre to microlitre (25 nL – 1.2 µL) volumes quickly and accurately in a cross-contamination free manner. The results demonstrate that this approach can be used for automated high-throughput generation of high quality RNA sequencing libraries from extremely low sample inputs.

Other examples of using mosquito liquid handlers in single-cell genomic applications (both RNA and gDNA) are detailed in our recent application note from Stephen Quake and Irving Weissman’s labs. One study used this miniaturisation method to identify novel bacterial species from environmental metagenomic samples. TTP Labtech’s mosquito X1 and HTS were used for normalisation and library prep at low volumes. In the second study, RNA expression was examined in single-cell analysis of macrophages from healthy and abnormal mouse tissues. The total DNA (gDNA or cDNA) required for these studies was reduced down 60 – 80pg.

>>Download the app note to read more about these assays.

If you are attending SLAS2016 then come along on Tuesday 26th January 2016 to Dr. Laurent’s presentation at 12:30 to 1:15 pm (Room 1A) or take a look at our poster between 1 – 3 pm. Alternatively, come and speak to our experts on booth 621 anytime during the conference.

For more information about the presentation please click here

press release: NEW Fluorescence Lifetime Platform Unveiled at SLAS

Integrated ameon Lifetime Reader and FLEXYTE Lifetime Reagents for Efficient Drug Discovery on show at TTP Labtech Booth 621

Melbourn, UK, 20 January 2016. Combining their well-established expertise in drug discovery automation plus peptide and protein engineering and manufacture, TTP Labtech and Almac Group have formed a strategic partnership to bring a fully integrated fluorescence lifetime platform. Being launched on Booth 621 at the Society for Laboratory Automation and Screening (SLAS) Conference in San Diego, USA the new platform comprises TTP Labtech’s new ameon® lifetime reader and Almac’s FLEXYTE® lifetime assays and reagents for precise lifetime assays, to provide a simple one-stop shop for robust, cost-effective drug screening and profiling.

On the booth, the new compact ameon lifetime reader will be on show which offers a step-change in lifetime data acquisition. Experts will also be on hand to explain how the reader can be combined with FLEXYTE lifetime reagents for the screening of common drug targets such as protein kinases and proteases, as well as challenging epigenetic targets. Applying such a powerful combination allows researchers to reduce compound-related assay interference, select fewer false leads and obtain the reliability normally associated with biophysical methods at the compound screen stage.

For scientists wanting to find out more about the unrivalled advantages of this accessible lifetime technology, there is a lunch tutorial entitled “An exciting talk: use of fluorescence lifetime technologies for high-throughput protein kinase screening and profiling” delivered by leading industry speakers on Monday 25th January from 12.30-13.15 in Room 1A. Please click the link to register There are also poster presentations from AstraZeneca and GlaxoSmithKline detailing their recent experience with the platform.

Dr Wayne Bowen, CSO at TTP Labtech, stated: “We have listened, and in partnership with major pharma companies, have developed an intelligent approach to improve the efficiency of compound screening. Most screening methodologies continue to be impacted by too many false hits and the limited throughput of orthogonal biophysical technologies; the intrinsic robustness of Almac’s FLEXYTE lifetime reagents coupled with the precision of TTP Labtech’s new ameon lifetime reader sets a new benchmark for cost-effective screening through better discrimination of lead compounds at an earlier stage within the drug discovery process.”

Dr Charles Shields, VP of Peptides & Small Molecule API at Almac commented: “We believe that the strategic partnership between TTP Labtech and Almac will bring to the screening community a true step-change in assay performance with the ability to uncover previously obscured leads and the potential to access new chemical space.”


11 Dec - 15 Dec 2016 meet our experts at this years Antibody Engineering & Therapeutics

Venue: Manchester Grand Hyatt San Diego, CA
Date: 11 Dec – 15 Dec 2016
Booth: #208

Join us at Antibody Engineering & Therapeutics

follow #antibodyeng on Twitter
Meet the team at the largest meeting that is devoted to Antibody Engineering!

We will be showcasing mirrorball, our versatile, high sensitivity, plate-based laser scanning cytometer optimised for antibody discovery and our sol-R coded beads for multiplexed fluorescence-based ELISAs and cell-based assays.
Download the brochure here!

Don’t miss the presentation by John Silva, Senior Principal Scientist at UCB Celltech

Title: High Throughput Antibody Discovery – Deeper Profiling of Antibodies during Primary Screening
Date: 14 Dec 2016
Time: 12 pm

UCB’s core antibody discovery platform combines automated high-throughput B-cell culture screening and the identification and isolation of single, antigen-specific IgG-secreting cells.

We demonstrate the use of the TTP Labtech mirrorball platform in primary antibody binding assays and in multiplex antibody screening to specifically identify cross-reactive hits. In addition, we have also applied the technology for screening for antibody functional activity.

For more information about the event please click here


29 Nov - 30 Nov 2016 meet the team at ELRIGfr

Venue: Ens, Lyon, France
Date: 29 Nov – 30 Nov 2016
Booth: TBC

Visit the TTP Labtech team at the 6th ELRIGfr conference. Two days of conferences, workshops, poster presentations and a closing networking party.



For more information please visit:

22 Nov - 23 Nov 2016 ease the flow of cytometry & imaging at ELRIG

Venue: GlaxoSmithKline, Stevenage, UK
Date: 22 Nov – 23 Nov 2016
Booth: A5

Join us at the 5th Biennial Pharmaceutical Flow Cytometry and Imaging meeting

We’ll be showcasing our plate-based mirrorball fluorescence cytometer, the perfect compliment for your flow cytometer!
>> Download the brochure


Designed for discovery, with mirrorball you can:

  • improve your workflow efficiency and cost effectiveness
  • gain data-driven decisions faster (just 12 mins for a 96-, 384- and 1536-well plate)
  • analyse beads, suspension cells and adherent cells without having to suspend
  • eliminate delays from flow cell clogging
  •  use just 500 cells per assay to enable primary cell screening
  • automate for walk-away robotic operation

Our team can also discuss with you our instruments used for:

  • flexible sample management workflows from ambient to -80°C (comPOUND, arktic, lab2lab)
  • unique low volume liquid handling for NGS, compound screening and MALDI-TOF (mosquito, dragonfly).

For more information about the 5th Pharmaceutical Flow Cytometry & Imaging meeting, please click here!


Want to see more process efficiencies?

>> Download our app note – phenotypic screening using a homogenous RSV neutralisation assay

This application note describes a simple, safe and robust high throughput screening approach for identifying neutralizing antibodies against respiratory syncytial virus using a plate-based cytometry approach.

How do your current processes compare?
Click here to arrange a personal review of your discovery processes with one of our specialists today!

13 Nov - 15 Nov 2016 talk about mosquito Crystal at PSDI

Venue: Clarion Hotel & Congress Malmö Live
Date: 13 Nov – 15 Nov 2016
Booth: TBC

Meet us at this year’s PSDI and see our mosquito Crystal

The 24th PSDI meeting will be help at the Clarion Hotel & Congress Malmö Live Sweden. Visit our team and learn more about the protein crystallographer’s favourite robot mosquito Crystal and our other liquid handlers and consumables range optimised for protein crystallographers.

With mosquito Crystal, you can use smaller volumes of precious protein sample with no risk of cross contamination. This results in cost savings and allows more extensive screening. You can automate all the popular protein crystallisation screening techniques – hanging drop, sitting drop and microbatch as well as seeding or additive screening plate preparation – without the need to make set-up changes to the instrument.

For more information about mosquito Crystal please click on the following:

For more information about PSDI 2016 visit the website at:


7 Nov - 8 Nov 2016 focus on lab2lab at UKASF 2016

Venue: Imperial War Museum, Duxford, Cambridgeshire, UK
Date: 7 Nov – 8 Nov 2016
Booth: TBC

Join us at UKASF and discover the benefits of lab2lab

The aim of the UKASF is to share best practice and review new technologies for the small and large scale chemical environment. Our team will be on hand to share with you the benefits of our automated sample transport and scheduling system for connecting scientists to centralised instrumentation, lab2lab.


>> watch our video: Novartis on “Connecting remote laboratories with analytical instrumentation”

>> read our related app note: lab2lab: a virtual analytical instrument in every laboratory – case study with Novartis

For more information about the event click here

For information about the UKASF visit their LinkedIn network group