Through strong investment in its internal and external programs, Dart NeuroScience (DNS) is driving new scientific discovery with some of the leading experts in this field. Its unique approach originated from scientific findings at the Cold Spring Harbor Laboratory that identified the genes controlling fruit fly memory. By extending the functional links of these genes to the memory of mammals, DNS has been able to apply new and advanced methodologies to identify small molecular drugs from mammalian targets. The group is screening newly discovered gene targets involved with memory formation against small molecule compounds in order to identify those that enhance or inhibit their biochemical activity. This is allowing DNS to fill its pipeline with exciting drug candidates for new targeted therapies and memory enhancers. By utilising its integrated teams of structural biologists, medicinal chemists, production and purification specialists, the organisation aims to apply its target-based molecule design to create and store up to 100,000 compounds a year.
“We are delighted to announce TTP Labtech as the chosen supplier of our compound management solution. We are investing heavily in our IP portfolio and developing our own proprietary compounds in-house. As such, identifying a secure solution that will ensure compound integrity and guarantee the protection of this investment has been paramount,” commented Jose Quiroz, Manager of Laboratory Systems at Dart NeuroScience.
With a small footprint, fast automated operation and a flexible, modular design, comPOUND will prove a sturdy investment for the DNS team. “We know that TTP Labtech’s comPOUND-comPILER platform will provide the exceptional long-term storage and tube-to-plate processing capabilities that we require,” Quiroz said.
Scalability and future proofing was also a key factor for the group at DNS. “We are starting with three comPOUNDs and one comPILER system, but with the scope to integrate up to ten comPOUND stores simultaneously with our comPILER platform, we can sensibly amortize our investment. This is something that is not possible with a big integrated store requiring a significant capital outlay. Instead, we can effectively grow our library and our storage facilities in parallel – this is very appealing to us.”
James Craven, Product Manager for sample storage at TTP Labtech, described the new agreement as “collaborative” and a great example of the unique approach that the company brings to its sales process. “We’ve worked closely with the screening and compound management teams at DNS for a number of years, supplying other products such as our mosquito and acumen, and were keen to help them find a future-proofed compound management system,” he said. “By working very closely alongside the DNS team, we could propose a comPOUND-comPILER set-up coupled with our pneumatic tube transport system, lab2lab, with everything working seamlessly together to meet their unique requirements and objectives.”