University of Michigan

An exciting technological collaboration integrating TTP Labtech’s mosquito® X1 automated nanolitre pipettor with a well-known microplate mover has been set up bringing an innovative hit-picking solution to the University of Michigan. This fully automated system is being utilised by the University’s High Throughput Screening (HTS) Core, Center for Chemical Genomics, to automate the selection and processing of compound hits from
screens, using their 150,000 strong library.

“The mosquito X1 instrument has proven revolutionary in increasing the throughput of
our hit selection service.” said Martha Larsen, Director of HTS, University of Michigan.  She continued “It is particularly important to us that the mosquito X1 can cherry-pick the compounds from the storage plates, and that the instrument can perform dose response dilutions for use in our secondary screening stage.  Before we purchased the mosquito we prepared dose response 384-well plates by hand and had to limit screens to 200 compounds a time. With the mosquito X1 we have been able to significantly increase our screening rate and throughput.”

Joby Jenkins, Product Manager, TTP Labtech commented: “The mosquito X1 instrument provides the speed and efficiency required for HTS facilities. We have worked closely with the HTS Core to provide a platform that is optimised to meet their specific needs. The ability to transfer compounds within a complex, high density microplate format, while avoiding cross-contamination, can boost the throughput of any screening service. Coupling the mosquitoX1 instrument with a microplate mover creates a platform that provides a level of walk-away confidence and greater workflow efficiency. We are delighted that this system has had such a positive effect on their workflow practices.”