any liquid, any volume, any well, any time
The complexities of assay development, and challenges associated with validating and transferring assays into HTS are well known bottlenecks in the drug discovery process. TTP Labtech have sought to address this with the application of a novel liquid handling technology within a range of user friendly, low volume liquid handling instruments that significantly reduce assay development time and greatly improve assay robustness in screening.
Premiered at SLAS2017, dragonfly discovery – it is set to be a game-changing solution to challenges in assay development and high throughput screening!
Watch the SelectScience interview with our Director, Product Strategy, Joby Jenkins about dragonfly discovery!
Request access to our SLAS2017 workshop video – Assay development into HTS: redefining reagent dispensing, presented by Melanie Leveridge, Head Screening, Profiling & Mechanistic Biology, GSK and Joby Jenkins, Director, Product Strategy, TTP Labtech.
delivering screening efficiency through technology innovation
dragonfly discovery gives scientists a common platform whereby they can easily develop complex assays, validate and screen them in a reliable, robust and cost efficient manner
This innovative technology enables assays to be developed directly in high density (up to 1,536-well) plate format using a common liquid handling platform that can also perform assay validation and subsequent HTS. The commonality of dispense technology, combined with reliability of dispensing not only simplifies the process of assay development, but also significantly aids the smooth transition in to HTS. The versatility of the instrument provides the ideal platform for hit to lead and lead optimisation, thus enabling the same dispense technology to be used throughout the drug discovery process.
more than just dispensing
non-contact dispensing from a disposable, positive displacement tip
In each of the channels (up to 10) there is a tight fitting piston that travels within a pipette barrel, when coupled to the instruments piston rod the positive displacement syringe is formed. The distance and rates of acceleration and deceleration of the piston control how and when liquid is ejected from the tip.
Each channel is fully independent of the others, yet they can all be operated simultaneously, giving rapid, but highly flexible dispensing. This enables complex combination gradients to be set up in high density (up to 1,536 well) microplates, as well as high speed bulk filling of common reagents.