protein crystallisation screening with mosquito® Crystal

TTP Labtech’s mosquito Crystal is the protein crystallographer’s favourite robot. It makes protein crystallisation screening faster, more cost-effective and quite simply easier than ever before.

With mosquito Crystal, you can use smaller volumes of precious protein sample with no risk of cross contamination. This results in cost savings and allows more extensive screening. You can automate all the popular protein crystallisation screening techniques – hanging drop, sitting drop and microbatch as well as seeding or additive screening plate preparation – without the need to make set-up changes to the instrument.

mosquito’s accuracy and repeatability means you can place drops centrally in the sub-wells of sitting drop plates every time. Precise drop placement facilitates automated plate imaging, thus making your protein crystals easier to identify.

TTP Labtech’s mosquito Crystal also allows you to create several multiple component drops per well in 96-well hanging drop set-ups, allowing you to assess different protein concentrations, ligands or complexes at the same time.

mosquito’s unique nanolitre liquid handling technology can perform multiple aspirations before a single dispense, which is essential for automating seeding and direct addition of additive screens to the drops. You can even dispense a combination of solutions simultaneously – with additional mixing if required – ensuring perfect drop formation for optimal protein crystallisation.

 

webinars

>>Crystallography platforms for iterative protein-ligand complex determination

>>A crystallisation strategy focussed on a high throughput seeding technique

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